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Education

PhD, Immunology and Microbiology, Wayne State ¾Å¾Å¸£ÀûÍø School of Medicine, 2010

BS, Medical Technology, ¾Å¾Å¸£ÀûÍø of Michigan, 2005

Research Interest

The overall goal of my research is to explore mechanisms by which cellular stress responses regulate innate immunity to bacterial infection.  

Teaching Interest

I am interested in teaching topics that cover bacterial pathogenesis, immunology, molecular biology, and cell biology. I am also interested in mentoring students with different levels of education including undergraduate, veterinary, and graduate students. 

Awards & Honors

2016, The American Association of Immunology (AAI) Young Investigator Award

2015, Midwest Microbial Pathogenesis Conference Selected Speaker Award

2006, Maize and Blue Award for Distinguished Scholarship (¾Å¾Å¸£ÀûÍø of Michigan) 

Publications

Abuaita BH, Lawrence A-LE, Berger RP, Hill DR, Huang S, Yadagiri VK, et al. Comparative transcriptional profiling of the early host response to infection by typhoidal and non-typhoidal Salmonella serovars in human intestinal organoids. PLoS Pathog 2021;17:e1009987.

Abuaita BH, Sule GJ, Schultz TL, Gao F, Knight JS, O’Riordan MX. The IRE1α Stress Signaling Axis Is a Key Regulator of Neutrophil Antimicrobial Effector Function. J Immunol 2021.

Lawrence A-LE, Abuaita BH, Berger RP, Hill DR, Huang S, Yadagiri VK, et al. Salmonella enterica Serovar Typhimurium SPI-1 and SPI-2 Shape the Global Transcriptional Landscape in a Human Intestinal Organoid Model System. MBio 2021;12.:

Sule G, Abuaita BH, Steffes PA, Fernandes AT, Estes SK, Dobry C, et al. Endoplasmic reticulum stress sensor IRE1α propels neutrophil hyperactivity in lupus. J Clin Invest 2021;131.: https://doi.org/10.1172/JCI137866. 
Gao F, Reynolds MB, Passalacqua KD, Sexton JZ, Abuaita BH, O’Riordan MXD. The Mitochondrial Fission Regulator DRP1 Controls Post-Transcriptional Regulation of TNF-α. Front Cell Infect Microbiol 2020;10:593805.

Abuaita BH, Schultz TL, O’Riordan MX. Mitochondria-Derived Vesicles Deliver Antimicrobial Reactive Oxygen Species to Control Phagosome-Localized Staphylococcus aureus. Cell Host Microbe 2018;24:625–36.e5. 
Bronner DN, Abuaita BH, Chen X, Fitzgerald KA, Nuñez G, He Y, et al. Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3- and Caspase-2-Driven Mitochondrial Damage. Immunity 2015;43:451–62.

Abuaita BH, Burkholder KM, Boles BR, O’Riordan MX. The Endoplasmic Reticulum Stress Sensor Inositol-Requiring Enzyme 1α Augments Bacterial Killing through Sustained Oxidant Production. MBio 2015;6:e00705.

Runft DL, Mitchell KC, Abuaita BH, Allen JP, Bajer S, Ginsburg K, et al. Zebrafish as a natural host model for Vibrio cholerae colonization and transmission. Appl Environ Microbiol 2014;80:1710–7.

Abuaita BH, Withey JH. Bicarbonate Induces Vibrio cholerae virulence gene expression by enhancing ToxT activity. Infect Immun 2009;77:4111–20. 

Grant Funding

Relieving ER stress in lupus neutrophils, Lupus Research Alliance (LRA), Co-Investigator, 12/2019-11/2021. 
Control of neutrophil effector mechanisms by the IRE1-Caspase-2 signaling axis, NIH/NIAID R21, Co-Investigator, 06/2018-05/2020.

Induction of the macrophage unfolded protein response (UPR) by MRSA infection enhances anti- microbial function. American Heart Association-Midwest Affiliate Postdoctoral Fellowship, Principal Investigator, 07/2013-06/2015.